As you venture deeper into the Rhodes Hill Care Center in Resident Evil Requiem , your search for the escape items will lead you to the Lead Researcher’s Office . Inside, you’ll find another locked Puzzle Box like the one in the Chairman's Office , containing a vital progression item.

However, unlike the Chairman’s puzzle box, you cannot interact with this one straight away. You’ll need a specific item to bypass a physical lock first.

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Before you can even worry about the combination, you will notice the Puzzle Box is secured by a heavy padlock . This cannot be broken by any of Grace's tools and must be dissolved using the Corrosive , which is located inside the Conference Room .

If you want to find the solution yourself, you will need to check out the photos scattered around the office. Each one provides a piece of the puzzle's solution in the background.

Opening the box rewards you with two important items:

• The Sun Quartz: This is the second of the three critical items needed to escape the Rhodes Hill Care Center.
• Organ transport box note: a note containing the instructions on how to unlock the organ transport box found in the care center's Garage . The artificial organ stored inside is crucial to solving a later puzzle.

This concludes the guide. For more help with settings and survival strategies, visit our Resident Evil Requiem Complete Walkthrough and Guides Hub.

Guides based on a full playthrough completed in the Steam 1.0 version at Standard (Classic) difficulty. Screenshots captured from the same version.

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