In Cities: Skylines II, players build detailed cities at an epic scale. Intricate economic systems present players with choices that have ripple effects across the city. Dynamic maps set in various biomes present both challenges and opportunities for city builders. High-fidelity visuals showcase the beauty of cities like never before, from a humble city block to an iconic city skyline. For the first time ever, each citizen has their own individual life, including occupation, household, relationships and more, making cities feel alive. Players can now follow how their choices affect citizens' lives, adding weight and immediate impact to every strategic decision.

Players start by picking a map, with each environment presenting its own challenges, climate, and opportunities. From there, players manage a series of interconnected simulation systems as they build and grow their city. Build roads, lay out districts, set up infrastructure, and manage citizens' needs as the population grows from a small town to a sweeping metropolis.