At its Financial Analyst Day 2025, AMD shared new details about its upcoming Instinct MI400 and MI500 AI accelerators. The Instinct MI400 series set to launch in 2026, will be based on the new CDNA 5 architecture. AMD claims it will deliver up to 40 FP4 and 20 FP8 PFLOPs, roughly twice the compute performance of the current MI350. The GPUs also move to HBM4 memory from HMB3e, increasing capacity from 288 GB to 432 GB and raising total bandwidth from 8 TB/s to 19.6 TB/s. Each GPU provides 300 GB/s of scale-out bandwidth and adds broader AI data format support along with expanded AI pipelines. Two models are planned: the Instinct MI455X for large-scale AI training and inference, and the MI430X for HPC and sovereign AI. The MI430X features FP64 hardware based support and hybrid CPU+GPU compute capability, while retaining the same HBM4 memory subsystem as the MI455X. The MI400 series also moves away from the CoWoS-S to the CoWoS-L (Local Silicon Interconnect) advanced packaging technology.

AMD compares the MI400 lineup to NVIDIA's upcoming Vera Rubin series, claiming similar compute performance and memory bandwidth, but 1.5× higher memory capacity and scale-out bandwidth. During her presentation, Dr. Lisa Su said that AMD's Instinct MI400 accelerators will be available to clients and partners from day one, while the next-generation MI500 is already in advanced design stages. AMD is also now moving to an annual refresh cycle for its Instinct products, confirming that its next-gen MI500 series will be launched in 2027.