ASUS introduced the Pro WS B850M-ACE SE, an AMD Socket AM5 motherboard in the microATX form-factor that's laid out like a server motherboard, but targets a range of consumers spanning from home and small-business servers, to workstations with storage-heavy loadouts. The board draws power from a combination of 24-pin ATX, and 8+4 pin EPS. It supports the entire range of consumer Ryzen and commercial Ryzen PRO desktop processors from the Ryzen 7000 and Ryzen 9000 series. It also supports EPYC 4005 series server processors in the AM5 package. The board also supports ECC DDR5 unbuffered memory, with support for up to 256 GB of dual-channel (4 sub-channel) DDR5-5600 memory.

Among its use case-specific features are IPMI, U.2, and PCIe Gen 4 MCIO NVMe interfaces. The IPMI is driven by an ASPEED AST2600 chip that includes ASUS Control Center Express IT management software. Storage options include two M.2-2280 slots each with PCI-Express 5.0 x4 wiring, a PCIe Gen 4 MCIO, a U.2 Gen 3, and four SATA 6 Gbps ports. There's also an internal microSD slot for software key storage. There are three wired LAN interfaces—a 10 GbE driven by a Realtek RTL8127 PHY, a 2.5 GbE driven by Intel i225 series controller, and a third 1 GbE interface for the IPMI controller. USB interfaces include two 10 Gbps USB-C ports on the rear panel, a 20 Gbps USB-C header, three 10 Gbps USB type-A, an internal type-A, and additional 5 Gbps ports via headers. Display outputs include HDMI and DisplayPort from the iGPU, and a D-Sub from the IPMI chip. The board is expected to be priced around the $400 mark.